Limb trophischen Geschwüren]
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    Limb trophischen Geschwüren

    Een privacyherinnering van Google Nu bekijken Ik lees dit later. Geavanceerd zoeken naar patenten. Vermittler von "hedgehog" übermittelnden bahnen, dazugehörige zusammenetzungen und verwendungen Broker "hedgehog" pave the sending, associated together menet tions and uses vertaald uit het Duits DE T3.

    Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Hemmung der Aktivierung eines Hedgehog-Wegs in einer Zelle als Teil einer therapeutischen oder kosmetischen Anwendung, limb trophischen Geschwüren, ausgewählt aus der Regulierung von neuralem Gewebe, Knochen- und Knorpelausbildung und -wiederherstellung, Regulierung der Spermatogenese, Regulierung von glatter Muskulatur, Regulierung von Lunge, Leber und anderen Organen, die aus dem primitiven Darmkanal entstehen, Regulierung der hämatopoetischen Funktion und Regulierung von Haut- und Haarwachstum, Behandlung von Basalzellenkarzinom, Hemmung des Haarwachstums und Hemmung von Zellwachstum oder -proliferation, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel Iist: Use of a compound for preparing a medicament for inhibiting activation limb trophischen Geschwüren a hedgehog pathway in a cell limb trophischen Geschwüren part of a therapeutic or cosmetic application is selected from regulation of neural tissues, bone and cartilage formation and recovery, regulation of spermatogenesis, regulation of smooth muscleregulation of lung, liver and other organs arising from the primitive gut channel, regulation of hematopoietic function, and regulation of skin and hair growth, the treatment of basal cell carcinoma, limb trophischen Geschwüren, inhibition of hair growth, and inhibition of cell growth or proliferation, wherein the compound is an organic molecule represented by the general formula I is: Verfahren zur Hemmung der Aktivierung eines Hedgehog-Wegs in einer Zelle, umfassend das Inkontaktbringen der Zelle in vitro mit einer Verbindung in einer ausreichenden Menge, um eine Hedgehog-Signalgebung zu inhibieren, wobei die Verbindung limb trophischen Geschwüren organisches Molekül, dargestellt durch die allgemeine Formel Iist: A method for inhibiting activation of a hedgehog pathway in a cell comprising contacting the cell in vitro with a compound in an amount sufficient to inhibit hedgehog signaling, wherein the compound is an organic molecule represented by the general formula I is: Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Hemmung der Aktivierung eines Hedgehog-Wegs in einer Zelle als Teil einer therapeutischen oder kosmetischen Anwendung, ausgewählt aus der Regulierung von neuralem Gewebe, Knochen- und Knorpelausbildung und -wiederherstellung, Regulierung der Spermatogenese, Regulierung von glatter Muskulatur, Regulierung von Lunge, Leber und anderen Organen, limb trophischen Geschwüren, die aus dem primitiven Darmkanal entstehen, Regulierung der hämatopoetischen Funktion und Regulierung von Haut- und Haarwachstum, Behandlung von Basalzellenkarzinom, Hemmung des Haarwachstums und Hemmung von Zellwachstum oder limb trophischen Geschwüren, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel IIIist: Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell as part of a therapeutic or cosmetic application is selected from regulation of neural tissues, bone and cartilage formation and recovery, regulation of spermatogenesis, regulation of smooth musclelimb trophischen Geschwüren, regulation of lung, liver and limb trophischen Geschwüren organs arising from the primitive gut channel, regulation of hematopoietic function, and regulation of skin and hair growth, the treatment limb trophischen Geschwüren basal cell carcinoma, inhibition of hair growth, and inhibition of cell growth or proliferation, wherein the compound is an organic molecule represented by the general formula IIIis: Verfahren zur Hemmung der Aktivierung eines Hedgehog-Wegs in einer Zelle, umfassend das Inkontaktbringen der Zelle in vitro mit einer Verbindung in einer ausreichenden Menge, um die Limb trophischen Geschwüren zu inhibieren, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel IIIist: A method for inhibiting activation of a hedgehog pathway in a cell comprising contacting the cell in vitro with a compound in a sufficient amount to inhibit hedgehog signaling, wherein the compound is an organic molecule represented by the general formula III is: Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Hemmung der Aktivierung eines Hedgehog-Wegs in einer Zelle als Teil einer therapeutischen oder kosmetischen Anwendung, ausgewählt aus der Regulierung von neuralem Gewebe, Knochen- und Knorpelausbildung und -wiederherstellung, Regulierung der Spermatogenese, limb trophischen Geschwüren, Regulierung von glatter Muskulatur, limb trophischen Geschwüren, Regulierung von Lunge, Leber und anderen Organen, limb trophischen Geschwüren, die aus dem limb trophischen Geschwüren Darmkanal entstehen, Regulierung der hämatopoetischen Funktion und Regulierung von Limb trophischen Geschwüren und Haarwachstum, Behandlung von Basalzellenkarzinom, Hemmung des Haarwachstums und Hemmung von Zellwachstum oder -proliferation, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel IVist: Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell as part of a therapeutic or cosmetic application is selected from regulation of neural tissues, bone and cartilage formation and recovery, regulation of spermatogenesis, regulation of smooth muscleregulation of lung, liver and other organs arising from the primitive gut channel, regulation of hematopoietic function, and regulation of skin and hair growth, the treatment trophischen Geschwüren wie Schmerzen basal cell carcinoma, inhibition of hair growth, and inhibition of cell growth or proliferation, wherein the compound is an organic molecule represented by the general formula IV is: Verfahren zur Hemmung der Aktivierung eines Hedgehog-Wegs in einer Zelle, umfassend das Inkontaktbringen der Zelle in vitro mit einer Verbindung in einer ausreichenden Menge, um die Hedgehog-Signalgebung zu inhibieren, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel IVist: A method for inhibiting activation of a hedgehog pathway in a cell comprising contacting the cell in vitro with a compound in a sufficient amount to inhibit hedgehog signaling, wherein the compound is an organic molecule represented by the general formula IV is: A method or use according to any one of claims 1 to 4, wherein Y and Z represent O, respectively.

    A method or use according to claim 1 or limb trophischen Geschwüren, wherein E is NR 8, limb trophischen Geschwüren. A method or use according to claim 1, limb trophischen Geschwüren, 2 or 8, wherein D is an aralkyl or heteroaralkyl-substituted amine. A method or use according to claim 3, 4, 5 or 6, limb trophischen Geschwüren, wherein M is absent. A method or use according to any one of the preceding claims, wherein X is included in a ring.

    A method or use according to any one of the preceding claims, wherein X is included in a diazacarbocycle. A method or use according to any preceding claim, wherein XLR 4 includes a cyclic amine. A method or use according to any one of the preceding claims, wherein at least one of the radicals R 1, R 2 and R 3 includes an aryl group. A method or use according to any one of the preceding claims, wherein R 1 represents a branched alkyl, cycloalkyl or cycloalkylalkyl.

    A method or use according to any one of claims 1 to 15, limb trophischen Geschwüren L in each occurrence represents a direct bond. Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Hemmung der Aktivierung eines Hedgehog-Wegs in einer Zelle als Teil einer therapeutischen oder kosmetischen Anwendung, ausgewählt aus der Regulierung von neuralem Gewebe, Knochen- und Limb trophischen Geschwüren und -wiederherstellung, Regulierung der Spermatogenese, Regulierung von glatter Muskulatur, Regulierung von Lunge, Leber und anderen Organen, die aus dem primitiven Darmkanal entstehen, Regulierung der hämatopoetischen Funktion und Regulierung von Haut- und Haarwachstum, Behandlung von Basalzellenkarzinom, Hemmung des Haarwachstums und Hemmung von Zellwachstum oder -proliferation, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel VIist: Use of a compound for preparing a limb trophischen Geschwüren for inhibiting activation of a hedgehog pathway in a cell as part of a therapeutic or cosmetic application is selected from regulation of neural tissues, bone and cartilage formation and recovery, regulation of spermatogenesis, regulation of smooth muscleregulation of lung, liver and other organs arising from the primitive gut channel, regulation of hematopoietic function, and regulation of skin and hair growth, the treatment of basal cell carcinoma, inhibition of hair growth, and inhibition limb trophischen Geschwüren cell growth or proliferation, wherein the compound is an organic molecule represented by the general formula VI is: Verfahren zur Hemmung der Aktivierung eines Hedgehog-Wegs in einer Zelle, umfassend das Inkontaktbringen der Zelle in vitro mit einer Verbindung in einer ausreichenden Menge, um die Hedgehog-Signalgebung zu inhibieren, wobei die Verbindung ein organisches Molekül, limb trophischen Geschwüren, dargestellt durch die allgemeine Formel VIist: A method for inhibiting activation of a hedgehog limb trophischen Geschwüren in a cell comprising, in order to inhibit contacting the cell in vitro with a compound in a sufficient amount of the hedgehog signaling, wherein the compound is an organic molecule represented by the general formula VI is: A method or use according to claim 18 or 19, wherein at least one occurrence of J is part of a heterocyclic ring having 5 to 8 members is.

    A method or use according to claim 18 or 19, wherein NJ 2 N, taken together, limb trophischen Geschwüren, represents a substituted or unsubstituted cyclic diamine. The method or use of claim 21, wherein limb trophischen Geschwüren cyclic diamine is a substituted or unsubstituted piperazine. A method or use according to any one of claims 18 to 32, wherein Y is O. A method or use according to any one of claims 18 to 34, wherein R limb trophischen Geschwüren is H or a C alkyl radical.

    A method or use according to any one of the preceding claims, wherein the cell having the phenotype of Ptc loss-function, Hedgehog gain-function or smoothened gain function. A method or use according to any one of the preceding claims, wherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 micron or less. A method or use according to any one of the preceding claims, wherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 nM or less.

    Use according to claim 1, 3, 5 or 18, wherein the therapeutic application is cancer cell growth or proliferation. A method or use according to any one of the preceding claims, wherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 mM or less.

    Arzneimittel, umfassend einen sterilen pharmazeutischen Exzipienten und eine Verbindung, dargestellt durch die allgemeine Formel VI: A pharmaceutical composition comprising a sterile pharmaceutical excipient and a compound represented by the general formula VI: Medicament according to claim 41, limb trophischen Geschwüren, wherein at least one occurrence of J is part of a heterocyclic ring, which comprises members.

    Medicament according to claim 41, wherein NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine, limb trophischen Geschwüren. Medicament according to claim 43, wherein the cyclic diamine is a substituted or unsubstituted piperazine. Medicament according to claim 43 or 44, wherein the cyclic diamine with one or more groups selected from oxo, C alkyl and substituted C alkyl. Medicament limb trophischen Geschwüren to claim 41, wherein NJ 2, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound to which the other occurrence of N.

    Medicament limb trophischen Geschwüren to claim 41, wherein NJR 9, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound to which the other occurrence of N. A pharmaceutical preparation according to any one of claims 41 to 47, wherein one or both occurrences of J with one or more groups selected from C alkyl, C alkyl, C -Alkylthioether, amido, and oxo substituted. Drugs one of claims 41 to 48, wherein R 5 represents a branched alkyl radical according to, cycloalkyl, or cycloalkylalkyl.

    A pharmaceutical preparation according to any one of claims 41 to 49, wherein R 6 includes at least one heterocyclic ring. Medicament according to claim 50, wherein the at least one heterocyclic ring is selected from thiophene, furan, oxazole, benzodioxane, Benzdioxol, pyrrole, and indole.

    Drugs one of claims 41 to 51, wherein R 7 represents accordance phenylalkyl. Medicament according to claim 52, wherein R 7 is a substituted or unsubstituted benzyl. Medicament according to claim 53, wherein the benzyl radical with one or more groups selected from halogen, hydroxyl, C limb trophischen Geschwüren, nitro, cyano, C alkyl and C -Alkylthioether substituted. Drugs one of claims 41 to 54, wherein R 8 is H or a C alkyl accordance.

    Drugs one of claims 41 to 55, wherein Y is O the same way. Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Behandlung von Krebs, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel Iist: Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula I is: Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula III is: Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Behandlung von Krebs, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel Nist: Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is limb trophischen Geschwüren organic molecule represented by the general formula N is: Use according to any of claims 58 to 59, wherein Y and Z represent O, respectively.

    Use according to claim 58, wherein E is NR 8. Use according to claim 58, 59 or 62, wherein D represents an aralkyl or heteroaralkyl-substituted amine. Use according to claim 59 or 60, wherein M is absent. Use according to one of claims 58 to 64, wherein X is included in a ring.

    Use according to any of claims 58 to 65, wherein X is included in a diazacarbocycle. Use according to any of claims 58 to 66, wherein XLR 4 includes a cyclic amine. Limb trophischen Geschwüren according to any of claims 58 to 67, wherein at least one of the radicals R 1, R 2 and R 3 includes an aryl group.

    Use according to any of claims 58 to 68, wherein R 1 represents a branched alkyl, cycloalkyl or cycloalkylalkyl. Use according to any of claims 58 to 70, wherein L in each occurrence represents a direct bond. Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Behandlung von Krebs, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel VIist: Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula VI is: Use according to claim 72, wherein at least one occurrence of J is part of a heterocyclic ring, which comprises members.

    Use according to claim 72, wherein NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine. Use according to claim 74, wherein the cyclic diamine is a substituted or unsubstituted piperazine, limb trophischen Geschwüren. Use limb trophischen Geschwüren to claim 75, wherein the cyclic diamine with one limb trophischen Geschwüren more groups selected from limb trophischen Geschwüren, C alkyl and substituted C alkyl.

    Use according to claim 72, wherein NJ 2, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound to which the other occurrence of N. Use according to claim 72, wherein NJR 9, taken together, represents a substituted or unsubstituted heterocyclic ring to which the other occurrence. Use according to any one of claims 72 to 78, wherein one or both occurrences of J with one or more groups selected from C alkyl, C alkyl, C -Alkylthioether, amido, and oxo substituted.

    Use according to any one of claimswherein R 5 represents a branched alkyl, cycloalkyl, or cycloalkylalkyl. Use according to any one of claims 72 to 80, limb trophischen Geschwüren R 6 includes at least one heterocyclic ring. Use according to claim 81, wherein the at least one heterocyclic ring is selected from thiophene, furan, oxazole, benzodioxane, pyrrole, and indole. Use according to any one of claimswherein R 7 is phenylalkyl.

    Use according to claim limb trophischen Geschwüren, wherein R 7 is a substituted or unsubstituted benzyl. Use according to claim 84, limb trophischen Geschwüren, wherein the benzyl radical with one or more groups selected from halogen, hydroxyl, C alkyl, nitro, cyano, C alkyl and C -Alkylthioether substituted. Use according to any one of claimswherein Y is O. Use according to any one of claimswherein R 8 is H or a C alkyl. Use according to any limb trophischen Geschwüren claims 58 to 88, wherein the cancer cells with a phenotype includes Ptc loss-function, Hedgehog gain-function or smoothened gain function, limb trophischen Geschwüren.

    Use according to any of claims 58 to 89 wherein the compound inhibits the transfer of Ptc-mediated loss of function, limb trophischen Geschwüren, hedgehog function increase or smoothened function signals increase with an ED 50 of 1 mM or less. Use according to claim 90, wherein the compound inhibits the transfer of Ptc-mediated loss of function, hedgehog function increase or smoothened function signals increase with an ED 50 of 1, limb trophischen Geschwüren.

    Use according to claim 91, wherein the compound inhibits the transfer of Ptc-mediated loss of function, hedgehog function increase or smoothened Fimktionszunahme signals with an ED 50 of 1 nM or less. Use according to any of claims 58 to 92 wherein the cancer is a basal cell carcinoma.

    Verbindung der Struktur der allgemeinen Formel VI: Compound having the structure of general formula VI: A compound according to claim 94, wherein at least one occurrence of J is part of a heterocyclic ring having 5 to 8 members is, limb trophischen Geschwüren. A compound according to claim 94, wherein NJ 2 N, taken together, is a substituted or unsubstituted cyclic diamine.

    A compound according to claim 96, limb trophischen Geschwüren the cyclic diamine is a substituted or unsubstituted piperazine. A compound according to claim 97, wherein the cyclic diamine with one or more groups selected from oxo, limb trophischen Geschwüren, C alkyl and C alkyl substituted.


    Trophischen Geschwüren Foto

    Vermittler von "hedgehog" übermittelnden bahnen, dazugehörige zusammenetzungen und verwendungen Broker "hedgehog" pave the sending, associated together menet tions and uses translated from German Limb trophischen Geschwüren T2.

    Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Hemmung der Aktivierung eines Hedgehog-Wegs in einer Zelle, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel Iist: Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell, limb trophischen Geschwüren the compound is an organic molecule represented by the general formula I is: Verfahren zur Hemmung der Aktivierung einer Hedgehog-Weg in einer Zelle, umfassend das Inkontaktbringen der Zelle in vitro mit einer Verbindung in einer ausreichenden Menge, um eine Hedgehog-Signalgebung zu inhibieren, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel Iist: A method of inhibiting activation of a hedgehog pathway in a cell comprising contacting the cell in vitro with a compound in an amount sufficient to inhibit hedgehog signaling, limb trophischen Geschwüren, wherein the compound is an organic molecule represented by the general formula I is: Use of a compound for preparing a medicament for inhibiting activation of a limb trophischen Geschwüren pathway limb trophischen Geschwüren a cell, wherein the compound is an organic molecule represented by the general formula III is: Verfahren zur Hemmung der Aktivierung einer Hedgehog-Weg in einer Zelle, umfassend das Inkontaktbringen der Zelle in vitro mit einer Verbindung in einer ausreichenden Menge, um die Hedgehog-Signalgebung zu inhibieren, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel IIIist: A method of inhibiting activation of a hedgehog pathway in a cell comprising contacting the cell in vitro with a compound in a sufficient amount to inhibit hedgehog signaling, wherein the compound is an organic molecule represented by the general formula III is: Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell, wherein the compound is an organic molecule represented by the general formula IV is: Verfahren zur Hemmung der Aktivierung einer Hedgehog-Weg in einer Zelle, umfassend das Inkontaktbringen der Zelle in vitro mit einer Verbindung in einer ausreichenden Menge, um die Hedgehog-Signalgebung zu inhibieren, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel IVist: A method of inhibiting activation of a hedgehog pathway in a cell comprising contacting the cell in vitro with a compound in a sufficient amount to inhibit hedgehog signaling, limb trophischen Geschwüren, wherein the compound is limb trophischen Geschwüren organic molecule represented by the general formula IV is: A method or use according to any one of claims 1 to 4, wherein Y and Z represent O, respectively.

    A method or use according to claim 1 or 2, wherein E is NR 8. A method or use according to claim 1, 2 or 8, wherein D is an aralkyl or heteroaralkyl-substituted amine.

    A method or use according to claim 3, limb trophischen Geschwüren, limb trophischen Geschwüren, 5 or 6, wherein M is absent. A method or use according to any one of the preceding claims, limb trophischen Geschwüren, wherein X is included in a ring. A method or use according to any one of the preceding claims, wherein X is included in a diazacarbocycle.

    A method or use according to any preceding claim, wherein XLR 4 includes a cyclic amine. A method or use according to any one of limb trophischen Geschwüren preceding claims, wherein at least one of the radicals R 1, R 2 and R 3 includes an aryl group. A Rehabilitation nach der Entfernung der Venen im Bein mit Krampfadern or use according to any one of the preceding claims, wherein R 1 represents a branched alkyl, cycloalkyl or cycloalkylalkyl.

    A method or use according to any one of claims 1 to 15, wherein L in each occurrence represents a direct bond. Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a die brauchen Bandagen für Krampfadern, wherein the compound is an organic molecule represented by the general formula VI is: Verfahren zur Hemmung der Aktivierung einer Hedgehog-Weg Thai-Creme für Krampfadern einer Zelle, umfassend das Inkontaktbringen der Limb trophischen Geschwüren in vitro mit einer Verbindung in einer ausreichenden Menge, um die Hedgehog-Signalgebung zu inhibieren, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel VIist: A method of inhibiting activation of a hedgehog pathway in a cell comprising, in order to inhibit contacting the cell in vitro with a compound in a sufficient amount of the hedgehog signaling, wherein the compound is an organic molecule represented by the general formula VI is: A method or use according to claim 18 or 19, limb trophischen Geschwüren, wherein at least one occurrence of J is part of a heterocyclic ring having 5 to 8 members is.

    A method or use according to claim 18 or 19, wherein NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine. The method or trophische Behandlung Geschwür zu Hause zu Fuß of claim 21, wherein the cyclic diamine is a substituted or unsubstituted piperazine. A method or use according to claim 22, limb trophischen Geschwüren, wherein the cyclic diamine with one or more groups selected from oxo, C alkyl and C alkyl substituted.

    A method or use according to claim 18 or 19, wherein NJ 2, taken together, form a substituted or unsubstituted heterocyclic ring to which the other occurrence of N is attached, represents.

    A method or use according to claim 18 or 19, wherein NJR 9, taken together, form a substituted or unsubstituted heterocyclic ring to which the other occurrence limb trophischen Geschwüren N is attached, represents.

    Substituted method or use of any one of claims 18 to 25, wherein one or both occurrences of J with one or more groups selected from C alkyl, C alkyl, C -Alkylthioether, amido, and oxo are. A method or use according to any one of claims 18 to 26, wherein R 5 represents a branched alkyl, cycloalkyl, or cycloalkylalkyl. A method or use according to any one of claims 18 to 27, wherein R 6 includes at least one heterocyclic ring. A method or use according to claim 28, wherein the at least one heterocyclic ring is selected from thiophene, furan, oxazole, benzodioxane, benzodioxole, pyrrole, and indole.

    A method or use according to any one of claims 18 to 29, wherein R 7 is phenylalkyl. Limb trophischen Geschwüren method or use according to claim 30, wherein R 7 is a substituted or unsubstituted benzyl. A method or use according to claim 31, wherein the benzyl radical with one or more groups selected from halogen, hydroxyl, C alkyl, nitro, cyano, C alkyl and C -Alkylthioether substituted.

    A method or use according to any one of claims 18 to 32, wherein Y is O. A method or use according to any one of claims 18 to 34, wherein R 8 is H or a C alkyl radical. A method or use according to any one of the preceding claims, wherein the cell having the phenotype of Ptc loss-function, Hedgehog gain-function or smoothened gain function.

    A method or use according to any one of the preceding claims, wherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or Physiotherapie für Krampfadern Wunden gain-function signals with an ED 50 of 1 micron limb trophischen Geschwüren less.

    A method or use according to any one of the preceding claims, wherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 nM or less. Use according to any of the preceding claims, wherein the compound is to be administered as part of a therapeutic or cosmetic application.

    Use according to claim 39, wherein the therapeutic or cosmetic application is selected from regulation of limb trophischen Geschwüren tissues, bone and cartilage formation and recovery, regulation of spermatogenesis, regulation of smooth muscle, regulation of lung, liver, and other organs, the primitive of the viscera arise, regulation of hematopoietic function and regulation of skin and hair growth.

    Use according to claim 39, wherein the therapeutic or cosmetic application is basal cell carcinoma. Use according to claim 39, wherein the therapeutic or cosmetic application is inhibition of hair growth. Use according to claim 39, wherein the therapeutic or cosmetic application is inhibition of cell growth or proliferation. Use according to claim 43, wherein the cell growth or cell proliferation is cancer cell growth or proliferation. A method limb trophischen Geschwüren use according to any one of the preceding claims, limb trophischen Geschwüren, wherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 mM or less.

    Arzneimittel, umfassend einen sterilen pharmazeutischen Exzipienten und eine Verbindung dargestellt durch die allgemeine Formel I: A pharmaceutical composition comprising a sterile pharmaceutical excipient and a compound represented by the general formula I: Arzneimittel, umfassend einen sterilen pharmazeutischen Exzipienten und eine Verbindung, dargestellt durch die allgemeine Formel III: A pharmaceutical composition comprising a sterile pharmaceutical excipient and a compound represented by the general formula III: Medicament according to claim 46, wherein E is NR 8.

    Medicament according to claim 47, wherein M is absent. A pharmaceutical preparation according to any one of claims 46 to 50, wherein at least one of the radicals R 1, R 2 and R 3 includes an aryl group. Drugs one of claims 46 to 51, wherein R 1 represents a branched accordance Alkykest, cycloalkyl or cycloalkylalkyl. A pharmaceutical preparation according limb trophischen Geschwüren any one of claims 46 to 52, wherein XLR 4 taken together include a cyclic amine.

    Drugs one of claims 46 to 53, wherein Y and Z are O according same. A pharmaceutical preparation according to any one of claims 46 to 54, wherein the radical R 1 is bonded to the LO, limb trophischen Geschwüren, S or NR 8. Drugs one of claims 46 to 54, limb trophischen Geschwüren, wherein L in each occurrence represents a direct bond according to. Arzneimittel, umfassend einen sterilen pharmazeutischen Exzipienten und eine Verbindung, dargestellt durch die allgemeine Formel VI: A pharmaceutical composition comprising a sterile pharmaceutical excipient and a compound represented by the general formula VI: Medicament according to claim 57, wherein at least one occurrence of J is part of a heterocyclic ring, which comprises members.

    Medicament according to claim 57, wherein NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine. Medicament according to claim 59, wherein the cyclic diamine is a substituted or unsubstituted piperazine. Medicament according to claim 59 or 60, wherein the cyclic diamine with one or more groups selected from oxo, C alkyl and substituted C alkyl. Medicament according to claim 57, wherein NJ 2, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound to which the other occurrence of N.

    Medicament according to claim 57, limb trophischen Geschwüren, wherein NJR 9, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound to which the other occurrence of N.

    A pharmaceutical preparation according to any one of claims 57 to 63, wherein one or both occurrences of J with one or more groups selected from C alkyl, C alkyl, C -Alkylthioether, amido, and oxo substituted.

    Drugs to any one of claims 57 to 64, wherein R 5 represents a branched alkyl radical according to, cycloalkyl, or cycloalkylalkyl. A pharmaceutical preparation according to any one of claims 57 to 65, wherein R 6 includes at least limb trophischen Geschwüren heterocyclic ring, limb trophischen Geschwüren. Medicament according to claim 66, wherein the at least one heterocyclic ring is selected from thiophene, furan, oxazole, benzodioxane, Benzdioxol, pyrrole, and indole.

    Drugs to any one of claims 57 to limb trophischen Geschwüren, wherein R 7 represents accordance phenylalkyl. Medicament according to claim 68, wherein R 7 is a substituted or unsubstituted benzyl. Medicament according to claim 69, limb trophischen Geschwüren, wherein the benzyl group with one of more groups selected from halogen, hydroxyl, C alkyl, nitro, cyano, Limb trophischen Geschwüren alkyl and C -Alkylthioether substituted.

    Drugs one of claims 57 to 70, wherein R 8 is H or a C alkyl accordance. Drugs one of claims 57 to 71, wherein Y is O the same way. Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Behandlung von Krebs, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel Iist: Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula I is: Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula III is: Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Behandlung von Krebs, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel IVist: Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula IV is: Use according to any one of claims 74 to 75, wherein Y and Z represent O, respectively.

    Use according to claim 74, wherein E is NR 8. Use according to claim 74, 75 or 78, wherein D represents an aralkyl or Heteroaralkylsubstituiertes amine. Use according to claim 75 or 76, wherein M is absent: Use according to any one of limb trophischen Geschwüren 74 to 80, wherein X is included in a ring, limb trophischen Geschwüren.

    Use according to any one of claims 74 to 81, wherein X is included in a diazacarbocycle. Use according to any one of claimswherein XLR 4 includes a cyclic amine. Use according to any one of claims 74 to 83, wherein at least one of the radicals R 1, R 2 and R 3 includes an aryl group.

    Use according to any one of claims 74 to 84, wherein R 1 represents a branched alkyl, cycloalkyl or cycloalkylalkyl. Use according to any one of claims 74 to 85, wherein L in each occurrence represents a direct bond.

    Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Behandlung von Krebs, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel VIist: Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula VI is: Use according to claim 88, wherein at least one occurrence of J is part of a heterocyclic ring, limb trophischen Geschwüren, which comprises members.

    Use according to claim 88, limb trophischen Geschwüren, wherein NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine. Use according to claim 90, wherein the cyclic diamine is a Die Diagnose der unteren Extremität Thrombophlebitis or unsubstituted piperazine. Use according to claim 91, wherein the cyclic diamine with one or more groups selected from oxo, C alkyl and substituted C alkyl.


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    Look up in Linguee; Suggest as a translation of "limping" weaker limb, dragging behind but Muskel- und Sehnenapparates sowie von trophischen Geschwüren.
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